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KMID : 1003820000040020071
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Journal Of The Korea Institute Of Oriental Medical Diagnostics
2000 Volume.4 No. 2 p.71 ~ p.84
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An Experimental Study on the Effect of Geijibokryunghwan, Dangguijakyaksan and Each Constituent Herb on Inhibition of Platelet Aggregation
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Kim Jong-Goo
Kim Chang-Hwan
Park Soo-Young
Kim Jong-Soo
Choi Jae-Yun
Kim Chul-Ho
Park Won-Hwan
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Abstract
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The cause that the increase of animality fat intakes, under exercise, fatness, adding the stress, advanced age etc., the occurrence rate of the circulation system disease has been increased. And the thrombosis importantly came to the front as the risk factor of these circulation system´s disease. Nowadays, the ischemic disease has especially discussed, for example the angina or myocardial infarction, originated in thrombosis that came from the platelet aggregation.
Platelet do not attache to the normal hemangicendothelial cell. But when it stimulated by endothelium peronia and so on, it attache to the injury endothelium or rise aggregation between the platelet. And the activation of abnormal platelet occur the platelet grume and thrombogenesis. So it bring up the occlusive angiosis, so to speak, cardiovascular disease, cerebrovascular disease, arterial sclerosis.
In oriental medical, the thrombosis in the category of blood stasis and this blood stasis present the generalize or local blood circulation disturbance that generated by all kinds of pathological fact or blood stream retention accompanying with a series of syndrome. As the syndrome, stabbing pain fixed at certain region, squamous and dry skin, fullness and pain of the chest and hypochondrium, firmness and fullness of the lower abdomen, black stool, dark purple tongue or with ecchymoses and petechiae etc. have been created. And it becomes the pathopoiesis cause that the convulsion and palpitation, severe palpitatiion, tympanites, the symtom complex with a mass or swelling in the abdomen, insanity. stricken by wind etc. Moreover, the drugs for invigorating blood circulation and eliminating blood stasis or drugs for removing blood stasis are used for all kinds of syndrome through the blood stasis. And the drugs for activating the blood circulation, such as salviae Radix, Angelime Sinensis Radix, Persime Semen, Achyranthis Radix, Cnidii Rhizoma, chrthurni Flos are used for that. And it is used to the herbs of insects that has strong effect about the disintergrating blood stasis such as Hirudo, Scolopendrae Corpus, Buthus, Lumbricus etc..
On this study, Geijibokryunghwan(GBH), Dangguijakyaksan(DJS) and the consisting herbs were used for investigating the platelet aggregation activity about drugs that used to improvement various symptoms created by the thrombosis in oriental medicine. GBH formula has as formula recorded in the ((Synopsis of the golden chamber>, action of ´eleminating the evil and not impairment of healthy energy´ and ´promoting the flow of QI and cold and heat, so used for the expel blood stasis herbs from the ancient. And DJS has ´the action of tonifing the blood and promting the function of liver´ and ´the action to reinforce the function of the spleen and to remove dampness through diuresis, as prescription keep on record in the ((Synopsis of the golden chamber》, so used for ´the deficiency of the liver function and the stagnation of blood´ and ´the deficiency of the spleen function and the stagnation of dampness´ from the ancient.
Therefore we investigated the restraint effect of GBH, DJS and the consisting herbs about the platelet agregation induced to the ADP, AA or collagen. The conclusion is following.
1. When it added the aggregation inducer after that it added GBH, DJS and individual consisting herbs in the PRP, the DJS present the restraint effect in platelet aggregation. And in the individual consisting herbs, Paeoniae Radix and Moutan Cortex Radicis, Angelime Sinensis Radix and Cnidii Rhizoma present the restraint effect
2. It showed the (+), (+,++) inhibition effect on the platelet aggregation in Paeoniae Radix·Hoelen, Paeoniae Radix·Moutan Cortex Radicis, Hoelen·Moutan Cortex Radicis, Paeoniae Radix·Cnidii Rhizoma, Hoelen * Cnidii Rhizoma etc.
3. In the aggregation inhibition activating on the difference of density, GBH & DJS present strong restraint effect to the aggregation state induced to collagen and the consisting herbs such as Paeoniae Radix, Moutan Cortex Radicis and Angeliaze Sinensis Radix also present the restraint effect lean on the density about the aggregation induced by the collagen.
4. It showed the strong inhibition effect about the aggregation induced by the collagen in Paeoniae Radix·Hoelen, Paeoniae Radix·Moutan Cortex Radicis, Paeoniae Radix·Cnidii Rhizoma, Hoelen·Moutan Cortex Radicis, Hoelen·Cnidii Rhizoma etc
Like this, as confirm GBH, DJS and the individual consisting herb´s restraint effect of platelet aggregation, We considerated that GBH, DJS and the individual consisting herbs have practical applicational value of clinical trial in the thrombosis caused by platelet aggregation.
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